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Biological engineering or bio-engineering (including biological systems engineering) is the application of concepts and methods of biology (and secondarily of physics, chemistry, mathematics, and computer science) to solve real-world problems related to life sciences or the application thereof, using engineering's own analytical and synthetic methodologies and also its traditional sensitivity to the cost and practicality of the solution(s) arrived at. In this context, while traditional engineering applies physical and mathematical sciences to analyze, design and manufacture inanimate tools, structures and processes, biological engineering uses primarily the rapidly developing body of knowledge known as molecular biology to study and advance applications of organisms and to create biotechnology. This may eventually include the possibility of biologically engineering machines and 3D printing that re-order matter at a molecular scale. Physicist Richard Feynman theorized about the idea of a medical use for these biological machines, introduced into the body, to repair or detect damages and infections. . Feynman and Albert Hibbs suggested that it might one day be possible to (as Feynman put it) "swallow the doctor". The idea was discussed in Feynman's 1959 essay There's Plenty of Room at the Bottom.
Industrial bio-engineering extends from the creation of artificial organs by technical means or finds ways of growing organs and tissues through the methods of regenerative medicine to compensate reduced or lost physiological functions (Biomedical Engineering) and to develop genetically modified organisms, i.e., agricultural plants and animals as well as the molecular designs of compounds with desired properties (protein engineering, engineering enzymology). In the non-medical aspects of bio-engineering, it is closely related to biotechnology, nanotechnology and 3D printing.
An especially important application is the analysis and cost-effective solution of problems related to human health (human bioengineering), but the field is much more general than that. For example, biomimetics is a branch of biological engineering which strives to find ways in which the structures and functions of living organisms can be used as models for the design and engineering of materials and machines. Systems biology, on the other hand, seeks to exploit the engineer's familiarity with complex artificial systems, and perhaps the concepts used in "reverse engineering", to facilitate the difficult process of recognition of the structure, function, and precise method of operation of complex biological systems.